Accuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging

Simple item page
dc.contributor.authorMorphis, Michaella
dc.contributor.authorvan Staden, Johan A.
dc.contributor.authordu Raan, Hanlie
dc.contributor.authorLjungberg, Michael
dc.contributor.authorSjögreen Gleisner, Katarina
dc.date.accessioned2024-08-22T05:35:24Z
dc.date.available2024-08-22T05:35:24Z
dc.date.issued2024
dc.description.abstract𝗣𝘂𝗿𝗽𝗼𝘀𝗲: This study aimed to assess the accuracy of patient-specific absorbed dose calculations for tumours and organs at risk in radiopharmaceutical therapy planning, utilizing hybrid planar-SPECT/CT imaging. 𝗠𝗲𝘁𝗵𝗼𝗱𝘀: Three Monte Carlo (MC) simulated digital patient phantoms were created, with time-activity data for mIBG labelled to I-123 (LEHR and ME collimators) and I-131 (HE collimator). The study assessed the accuracy of the mean absorbed doses for I-131-mIBG therapy treatment planning. Multiple planar whole-body (WB) images were simulated (between 1 to 72 h post-injection (p.i)). The geometric-mean image of the anterior and posterior WB images was calculated, with scatter and attenuation corrections applied. Time-activity curves were created for regions of interest over the liver and two tumours (diameters: 3.0 cm and 5.0 cm) in the WB images. A corresponding SPECT study was simulated at 24 h p.i and reconstructed using the OS-EM algorithm, incorporating scatter, attenuation, collimator-detector response, septal scatter and penetration corrections. MC voxel-based absorbed dose rate calculations used two image sets, (i) the activity distribution represented by the SPECT images and (ii) the activity distribution from the SPECT images distributed uniformly within the volume of interest. Mean absorbed doses were calculated considering photon and charged particle emissions, and beta emissions only. True absorbed doses were calculated by MC voxel-based dosimetry of the known activity distributions for reference. 𝗥𝗲𝘀𝘂𝗹𝘁𝘀: Considering photon and charged particle emissions, mean absorbed dose accuracies across all three radionuclide-collimator combinations of 3.8 ± 5.5% and 0.1 ± 0.9% (liver), 5.2 ± 10.0% and 4.3 ± 1.7% (3.0 cm tumour) and 15.0 ± 5.8% and 2.6 ± 0.6% (5.0 cm tumour) were obtained for image set (i) and (ii) respectively. Considering charged particle emissions, accuracies of 2.7 ± 4.1% and 5.7 ± 0.7% (liver), 3.2 ± 10.2% and 9.1 ± 1.7% (3.0 cm tumour) and 13.6 ± 5.7% and 7.0 ± 0.6% (5.0 cm tumour) were obtained for image set (i) and (ii) respectively. 𝗖𝗼𝗻𝗰𝗹𝘂𝘀𝗶𝗼𝗻: The hybrid WB planar-SPECT/CT method proved accurate for I-131-mIBG dosimetry, suggesting its potential for personalized treatment planning
dc.description.versionPublisher's version
dc.identifier.citationMorphis, M., van Staden, J. A., du Raan, H., Ljungberg, M., & Sjögreen Gleisner, K. (2024). Accuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging. EJNMMI physics, 11(2024), 50. https://doi.org/10.1186/s40658-024-00657-9
dc.identifier.issn2197-7364 (online)
dc.identifier.urihttps://doi.org/10.1186/s40658-024-00657-9
dc.identifier.urihttp://hdl.handle.net/11660/12759
dc.language.isoen
dc.publisherSpringerOpen
dc.rights.holderAuthor(s)
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/
dc.subjectMonte Carlo simulations
dc.subjectSIMIND
dc.subjecthybrid whole-body planar-SPECT/CT
dc.subject¹²³I
dc.subject¹³¹I
dc.subjectmIBG
dc.titleAccuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Morphis_Accuracy of patient-specific I-131 dosimetry_2024.pdf
Size:
1.47 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Medical Physics)