Pilot-scale wastewater surveillance for pathogenic yeasts in Mangaung, South Africa
| dc.contributor.advisor | Pohl-Albertyn, C. H. | en_ZA |
| dc.contributor.advisor | Albertyn, J. | en_ZA |
| dc.contributor.advisor | Musoke, J. | en_ZA |
| dc.contributor.author | Baker, Tyla | en_ZA |
| dc.date.accessioned | 2025-06-04T22:28:18Z | |
| dc.date.available | 2025-06-04T22:28:18Z | |
| dc.date.issued | 2025 | en_ZA |
| dc.description | Dissertation (M.Sc.(Microbiology))--University of the Free State, 2024 | en_ZA |
| dc.description.abstract | Considering the emerging concern posed by invasive fungal infections, it is important to study the dissemination and proliferation of pathogenic fungal species in the environment. It is crucial to identify major vectors that aid in the spread or act as a hub for pathogenic yeasts in order to prevent infections in susceptible individuals, which mainly include individuals who are immunocompromised or immunosuppressed. 𝘊𝘢𝘯𝘥𝘪𝘥𝘢, 𝘊𝘳𝘺𝘱𝘵𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘯𝘥 𝘙𝘩𝘰𝘥𝘰𝘵𝘰𝘳𝘶𝘭𝘢 species are commonly found in a variety of water sources with which humans are in frequent contact through daily activities like bathing, washing clothes and cooking. The World Health Organisation has recently published a list of priority pathogens in which fungi are classified into critical, high and medium-priority groups. 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 species are found in all three levels and 𝘊𝘳𝘺𝘱𝘵𝘰𝘤𝘰𝘤𝘤𝘶𝘴 species are in critical and medium groups. This further warrants the investigation into the possibility that infections may occur through contact with yeastcontaminated water. In addition, the close association between antifungal pollutants and yeast in water may induce antifungal resistance development, further complicating the effective treatment of these infections. Thus, it is important to investigate the presence and antifungal susceptibility of yeast found in water as well as to identify ways to monitor potential fungal outbreaks, including through wastewater surveillance. This review deals with the occurrence and infection risks posed by pathogenic yeasts in water as well as the possibility of these yeasts acquiring antifungal resistance due to the simultaneous presence of antifungal compounds from medical and agricultural runoff. | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11660/13087 | |
| dc.language.iso | en | |
| dc.publisher | University of the Free State | en_ZA |
| dc.rights.holder | University of the Free State | en_ZA |
| dc.subject | Pathogenic yeast | en_ZA |
| dc.subject | Water quality | en_ZA |
| dc.subject | Antifungal resistance | en_ZA |
| dc.subject | Azoles | en_ZA |
| dc.subject | Wastewater surveillance | en_ZA |
| dc.title | Pilot-scale wastewater surveillance for pathogenic yeasts in Mangaung, South Africa | en_ZA |
| dc.type | Dissertation |