Assessing adherence to recommended HIV Post Exposure Prophylaxis regimens prescribed to doctors working at the Free State Academic Complex in Bloemfontein, South Africa

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dc.contributor.advisorVan Vuuren, C.
dc.contributor.advisorPotgieter, S.
dc.contributor.authorAsmal, Taahir
dc.date.accessioned2022-03-01T11:58:59Z
dc.date.available2022-03-01T11:58:59Z
dc.date.issued2021-05
dc.description.abstractBackground: The prevalence of HIV infection in South Africa is one of the highest in the world and healthcare workers in this setting are particularly at risk of being infected through occupational exposures. All high-risk exposures to infective bodily fluids are considered as important, warranting the use of post exposure prophylaxis (PEP). This study determined adherence to PEP in doctors, regardless of specialty and rank. Methods: A cross sectional study was conducted by distributing a structured anonymous questionnaire to doctors working in 3 teaching hospitals in central South Africa. Results: A total of 233 of 400 distributed questionnaires were completed (response rate 58,2%) from 543 employed doctors across 3 different hospitals and over 16 specialties (coverage 42.9%). Almost all the respondents (84,7%) had at least one high risk exposure, with an average of 2,3 exposures per respondent. Most (49%) of the respondents were exposed when performing venesection. Majority (58%) thought that the exposure could have been avoided. Of those exposed, 83% used PEP at least once. Of those who took PEP, 56% stopped prematurely with 71% of them citing adverse side effects as the main reason. Workload impacted adherence negatively in at least 50% of respondents. Conclusion: Majority of doctors had more than two occupational exposures. Adherence to PEP is generally poor. This is mainly due to the side effect profile of PEP regimens used at the time of the study. The recent widespread availability of better tolerated ART drugs and more tolerable regimens for PEP, may improve adherence.en_ZA
dc.identifier.urihttp://hdl.handle.net/11660/11469
dc.language.isoenen_ZA
dc.publisherUniversity of the Free Stateen_ZA
dc.rights.holderUniversity of the Free Stateen_ZA
dc.subjectDissertation (M.Med. (Internal Medicine) -- University of Free State, 2021en_ZA
dc.subjectHIV – Human Immunodeficiency Virusen_ZA
dc.subjectPEP – Post Exposure Prophylaxisen_ZA
dc.subjectAIDS – Acquired immunodeficiency Syndromeen_ZA
dc.subjectART – Anti Retro Viral therapyen_ZA
dc.subjectPMTCT – Prevention of Mother to Child Transmissionen_ZA
dc.subjectNSI – Needle Stick Injuryen_ZA
dc.subjectFS – Free Stateen_ZA
dc.subjectUFS – University of the Free Stateen_ZA
dc.subjectDOH – Department of Healthen_ZA
dc.subjectHCW – Healthcare Workersen_ZA
dc.subjectRCT – Randomised Control Trialen_ZA
dc.subjectUKZN – University of Kwa Zulu Natalen_ZA
dc.subjectUAH – Universitas Academic Hospitalen_ZA
dc.subjectPH – Pelonomi Hospitalen_ZA
dc.subjectNDH – National District Hospitalen_ZA
dc.subjectNHLS – National Health Laboratory Serviceen_ZA
dc.subjectHPCSA – Health Professions Council of South Africaen_ZA
dc.titleAssessing adherence to recommended HIV Post Exposure Prophylaxis regimens prescribed to doctors working at the Free State Academic Complex in Bloemfontein, South Africaen_ZA
dc.typeDissertationen_ZA
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