A retrospective study to evaluate local control and freedom from biochemical failure in Prostate cancer treated with Hypo-fractionated split course 3D conformal radiotherapy at Universitas Academic Hospital, Bloemfontein, South Africa
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Date
2020-06
Authors
Mthombeni, Joseph M.
Journal Title
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Publisher
University of the Free State
Abstract
Background: Prostate cancer is the most common malignancy in men and the second most common cause of death for men in South Africa and universally. Three-dimensional conformal radiotherapy (3DCRT) is a safe and efficacious method to deliver radiation for prostate malignancy patients in all risk groups with acceptable toxicity rates and adequate biochemical control. AIM: To describe local control and freedom from biochemical failure in Prostate cancer patients treated with Hypo-fractionated split course external beam radiotherapy in a specified population for a given period. Methods: A retrospective descriptive cohort was conducted. Files of 142 patients with locally confined prostate adenocarcinoma who was treated at the Universitas Annex Hospital between 2003-2013 were reviewed. Data collected included demographics, risk factors, recurrence risk stratification, Gleason score, TNM staging, and PSA levels. Results: The prevalence of disease control was 108/142=76.1% at the end of the study period (60 months). The median age of the study participants was 68 years. Of the study participants, 40.14 % were white, 54.23% were black, and 5.63% were other races. At a median follow up of 5 years, all low-risk patients that participated in this study had disease control (local and biochemical), intermediate and high-risk patients with disease control were 12.68% and 59.15% respectively. The 34(23.9%) patients that had progression of the disease, 2.11% (3) and 21.83% (31) were intermediate and high risk, respectively. Conclusion: Hypo-fractionated split course 3DCRT in patients with localized prostate cancer has a significant locoregional disease control and freedom from biochemical failure.
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Keywords
Dissertation (M.Med. (Oncology))--University of the Free State, 2020, Prostate cancer, Locally confined, Radiotherapy, Hypofractionation, Biochemical failure, Split course, 3DCRT