Necrotising migratory erythema leading to the diagnosis of a metastatic glucagonoma without diabetes

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dc.contributor.advisorVan Vuuren, Cloete
dc.contributor.authorMakan, Rahm
dc.date.accessioned2021-05-13T13:57:49Z
dc.date.available2021-05-13T13:57:49Z
dc.date.issued2020-08
dc.description.abstractA case of necrotising migratory erythema (NME), which is one of the distinctive paraneoplastic skin manifestations associated with the glucagonoma syndrome, is described and discussed. In 80% of all patients with glucagonoma, NME is the first clinical sign. The glucagonoma syndrome is a constellation of clinical features: NME, weight loss, anaemia, diabetes, diarrhoea, thromboembolism and neuropsychiatric symptoms. The global incidence of glucagonoma is one in 20 million people per year. The male to female ratio is 0.8: 1 with the mean age of diagnosis being 52.2 years. The median time in relation to the initial onset of symptoms and the correct diagnosis is 3.5 years. The IO-year survival rate in patients with metastatic disease is 51.6% and without metastatic disease 64.3%. SPECT scan has a sensitivity range of 67-100% for detecting neuroendocrine tumours. Differential diagnoses of other skin conditions that mimic NME are: bullous pemphigoid, vasculitis, acrodermatitis enteropathica, chronic mucocutaneous candidiasis, seborrhoeic dermatitis, contact dermatitis, pellagra, inflammatory bowel disease, liver cirrhosis, coeliac disease, chemical bums, eczema, herpes etc. A satisfactory response to somatostatin as medical therapy in a casestudy patient with metastatic disease is reported.en_ZA
dc.identifier.urihttp://hdl.handle.net/11660/11083
dc.language.isoenen_ZA
dc.publisherUniversity of the Free Stateen_ZA
dc.rights.holderUniversity of the Free Stateen_ZA
dc.subjectDissertation (M.Med (Internal Medicine) -- University of Free State, 2020en_ZA
dc.subjectGlucagonen_ZA
dc.subjectGlucagonomaen_ZA
dc.subjectNeuroendocrineen_ZA
dc.subjectOcteotideen_ZA
dc.subjectSPECTen_ZA
dc.subjectSomatostatinen_ZA
dc.subjectPulmonary embolusen_ZA
dc.subjectVenous thromboembolismen_ZA
dc.subjectDiabetesen_ZA
dc.subjectNecrotising migratory erythema - Case studiesen_ZA
dc.subjectDiffuse skin rashen_ZA
dc.subjectChronic diarrhoeaen_ZA
dc.titleNecrotising migratory erythema leading to the diagnosis of a metastatic glucagonoma without diabetesen_ZA
dc.typeDissertationen_ZA
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