Green synthesis of Iron oxide and Iron dioxide nanoparticles using Euphorbia tirucalli: characterization and antiproliferative evaluation against three breast cancer cell lines

Simple item page
dc.contributor.authorKgosiemang, Ipeleng Kopano Rosinah
dc.contributor.authorAdegoke, Ayodeji Mathias
dc.contributor.authorMashele, Samson Sitheni
dc.contributor.authorSekhoacha, Mamello Patience
dc.date.accessioned2023-11-07T13:38:28Z
dc.date.available2023-11-07T13:38:28Z
dc.date.issued2023
dc.description.abstractResearchers have become increasingly interested in nanoparticles made from plants because of their stability and large surface area. In the current study, iron oxide and iron dioxide nanoparticles were synthesized using aerial parts of the E. tirucalli as a reducing agent. The nanoparticles were analyzed using various techniques, including Ultraviolet-visible spectroscopy, Fourier Transform Infrared spectroscopy, X-ray diffractometer, X-ray photoelectron spectroscopy, X-ray energy dispersive spectroscopy, Scanning electron Microscopy, and Transmission Electron Microscopy. The nanoparticles were then investigated for their antiproliferative effect against MCF-7, SK-BR-3, MDA-MB231, and Vero cell lines. The results confirmed the formation of FeO and FeO2 nanoparticles by color change and a UV absorbance peak between 220–390 nm. EDS analysis showed traces of Fe and O, while TEM confirmed the nanoparticle size of 100 nm. FTIR showed a peak at 514 nm. The FeO-RT NPs demonstrated over 80% antiproliferative activity against the MCF-7 cell line at a concentration of 10 μg/mL. while doxorubicin, FeO-RT NPs, and DCM extract showed similar activity against the MDA-MB231 cell line at 10 and 1 g/mL concentrations. However, Vero and SK-BR-3 cell lines showed decreased antiproliferative activity. This study highlights the environmentally friendly use and safe application of iron oxide NPs in cancer therapy.
dc.description.versionPublisher's version
dc.identifier.citationKgosiemang, I. K. R., Adegoke, A. M., Mashele, S. S., Sekhoacha, M. P. (2023). Green synthesis of Iron oxide and Iron dioxide nanoparticles using Euphorbia tirucalli: characterization and antiproliferative evaluation against three breast cancer cell lines. Journal of Experimental Nanoscience, 18(1). https://doi.org/10.1080/17458080.2023.2276276
dc.identifier.issn1745-8080 (print)
dc.identifier.issn1745-8099 (online)
dc.identifier.urihttps://doi.org/10.1080/17458080.2023.2276276
dc.identifier.urihttp://hdl.handle.net/11660/12333
dc.language.isoen
dc.publisherTaylor and Francis Group
dc.rights.holderAuthor(s)
dc.rights.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectEuphorbia tirucalli
dc.subjectiron oxide NPs
dc.subjectiron dioxide NPs
dc.subjectantiproliferation
dc.subjectbreast cancer cells
dc.titleGreen synthesis of Iron oxide and Iron dioxide nanoparticles using Euphorbia tirucalli: characterization and antiproliferative evaluation against three breast cancer cell lines
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kgosiemang_Green synthesis of Iron oxide_2023.pdf
Size:
3.91 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Plant Sciences)