Comparison between measured and simulated activity using Gafchromic™ film with radionuclides
| dc.contributor.advisor | Du Plessis, F. C. P. | |
| dc.contributor.advisor | Van Staden, J. A. | |
| dc.contributor.author | Joubert, Maria Magdalena | |
| dc.date.accessioned | 2021-05-13T06:57:57Z | |
| dc.date.available | 2021-05-13T06:57:57Z | |
| dc.date.issued | 2020-08 | |
| dc.description.abstract | In this study, Gafchromic™ film XR-QA2 and RT-QA2 were used to characterise the film energy response against various radionuclides. The film response was investigated with respect to different backscatter materials. The sensitivity of the two types of films was compared, and a film stack method was tested to allow the user to obtain sequential, cumulative doses at different time points. Monte Carlo (MC) simulations were used to link optical density (OD) values from measurements to the absorbed dose in the film. This was achieved by using conversion factors obtained by BEAMDP, BEAMnrc and DOSXYZnrc simulations to get the absorbed dose in the film. A neutron depletion theoretical model was introduced that can describe film response as a function of cumulated activity and absorbed dose. Background: Gafchromic™ film has been used for quality assurance in various studies but not in nuclear medicine applications. Once the OD has been determined after film exposure to a radionuclide, it can be linked to the absorbed dose using the air kerma rate constant at distances that approximates point sources and the dose in water can be linked to the dose in film using MC simulations to get conversion factors. MC simulations are known as a gold standard to get the absorbed dose in materials. Materials and Methods: XR-QA2 and RT-QA2 Gafchromic™ film were irradiated with the following radionuclides: Am-241, Cs-137, Tc-99m and I-131. The OD was calculated, and a function describing the relationship between the OD and the time-activity was derived based on the neutron depletion model. Different backscatter materials such as Corrugated fibreboard carton (CFC) or air equivalent material, polystyrene, Polymethyl Methacrylate (PMMA or perspex) and lead were used to investigate the effect it has on film response. The sensitivity of each film was investigated and compared. BEAMDP, BEAMnrc and DOSXYZnrc simulations were used to link the film response, OD, to the absorbed dose. The MC simulations were done replicating the exact geometry as with the physical measurements to get the absorbed dose in the film. Results: The new neutron depletion model fitted the OD vs cumulative activity accurately as well as the OD vs absorbed dose. The XR-QA2 Gafchromic™ film has shown to be the most sensitive film when using air equivalent material with radionuclides, especially with low energy radionuclides such as Am-241. When using more than one layer, the OD sensitivity of the film can be increased as well. The film stack method investigated also showed to be less time consuming when relating stacked film data to single film data. The fluence obtained from BEAMDP confirmed that the radionuclide containers have an effect on the radionuclide spectra’s. Lead was also the backscatter material which showed higher OD change but lower absorbed dose values. Conclusions: The neutron depletion theoretical model is more accurate than higher-order polynomial fits because it contains less free parameters. The XR-QA2 Gafchromic™ is better to use in nuclear medicine because of its sensitivity at low energies and because the sensitivity can be increased by using multiple layers of film. Film stack methods can be used to decrease experiment times. BEAMnrc can be used to accurately model radionuclides within their containers to evaluate the container effects. Lead showed a higher induced OD with lower absorbed dose, and the air equivalent material showed the lower OD change but higher absorbed dose. | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11660/11064 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | University of the Free State | en_ZA |
| dc.rights.holder | University of the Free State | en_ZA |
| dc.subject | Gafchromic™ film | en_ZA |
| dc.subject | XR-QA2 | en_ZA |
| dc.subject | RT-QA2 | en_ZA |
| dc.subject | Radionuclides | en_ZA |
| dc.subject | Monte Carlo | en_ZA |
| dc.subject | DOSXYZnrc | en_ZA |
| dc.subject | BEAMnrc | en_ZA |
| dc.subject | Simulations | en_ZA |
| dc.subject | Optical density | en_ZA |
| dc.subject | Cumulated Activity | en_ZA |
| dc.subject | Dissertation (M.Med.Sc. (Medical Physics))--University of the Free State, 2020 | en_ZA |
| dc.title | Comparison between measured and simulated activity using Gafchromic™ film with radionuclides | en_ZA |
| dc.type | Dissertation | en_ZA |