In vivo efficacy of curcumin and curcumin nanoparticle in trypanosoma congolense, broden 1904 (kinetoplastea: trypanosomatidae)-infected mice
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Date
2023
Authors
Molefe-Nyembe, Nthatisi Innocentia
Adeyemi, Oluyomi Stephen
Kondoh, Daisuke
Kato, Kentaro
Inoue, Noboru
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Curcumin (CUR) is known for its wide folkloric effects on various infections; however, its solubility status has remained a hindrance to its bioavailability in the host. This study evaluated the comparative effects of CUR and CUR-nanoparticle in vitro on T. congolense, T. b. brucei, and T. evansi. Additionally, CUR and CUR-nanoparticle anti-Trypanosoma efficacy were assessed in vivo against T. congolense. All the CUR-nanoparticles were two folds more effective on the T. congolense as compared to CUR in vitro, with recorded efficacy of 3.67 ± 0.31; 7.61 ± 1.22; and 6.40 ± 3.07 μM, while the CUR-nanoparticles efficacy was 1.56 ± 0.50; 28.16 ± 9.43 and 13.12 ± 0.13 μM on T. congolense, T. b. brucei, and T. evansi, respectively. Both CUR and CUR-nanoparticles displayed moderate efficacy orally. The efficacy of CUR and CUR-nanoparticles in vivo was influenced by solubility, presence of food, and treatment period. CUR-treated mice were not cured of the infection; however, the survival rate of the orally treated mice was significantly prolonged as compared with intraperitoneal-treated mice. CUR-nanoparticles resulted in significant suppression of parasitemia even though relapsed was observed. In conclusion, CUR and CUR-nanoparticles possess moderate efficacy orally on the trypanosomes as compared to the intraperitoneal treatment.
Description
Keywords
animal African trypanosomosis, drug discovery, nanomedicine, natural products, phytomedicine
Citation
Molefe-Nyembe, N. I., Adeyemi, O. S., Kondoh, D., Kato, K., Inoue, N., & Suganuma, K. (2023). In vivo efficacy of curcumin and curcumin nanoparticle in trypanosoma congolense, broden 1904 (kinetoplastea: trypanosomatidae)-infected mice. Pathogens, 12(10), 1227. https://doi.org/10.3390/pathogens12101227