Bridelia ferruginea tea consumption improves antioxidant status in individuals living with Type 2 Diabetes
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Date
2025-01-07
Authors
Appiah, Collins Afriyie
Ngounda, Jennifer
Boakye-Yiadom, Mavis
Mills-Robertson, Felix Charles
Nel, Mariette
Johnson, Rabia
Walsh, Corinna
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
šš®š°šøš“šæš¼šš»š±: It is well-known that persistent hyperglycaemia predisposes individuals with diabetes to oxidative stress. šš³šŖš„š¦ššŖš¢ š§š¦š³š³š¶šØšŖšÆš¦š¢ Benth., a tropical African plant, is known for its antioxidant activity.
š š²ššµš¼š±š: This comparative cross-sectional study assessed the oxidative status and associated parameters in 70 individuals living with type 2 diabetes (ILWT2D) who were receiving standard diabetes treatment and consistently drank Bridelia tea (Bridelia group) compared to 92 ILWT2D receiving standard diabetes treatment only (comparator group). Lipid peroxidation assessed using thiobarbituric acid reactive substances (TBARS) served as an indicator of oxidative stress. In addition, the total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), and dietary intake of antioxidant-rich foods were assessed.
š„š²ššš¹šš: The comparator group had significantly better glycaemic control [median HbA1cā7.7% (IQR 6.7ā9.4)] than the Bridelia group [9.2% (7.6ā11.4)], š± = 0.001. The comparator group had been on metformin treatment for a significantly longer period than the Bridelia group (š± < 0.0001). Participants in the comparator group consumed antioxidant-rich fruits more frequently (monthly basis) than those in the Bridelia group who ate fruits seldomly (š± < 0.0001). There was no significant difference (š± = 0.11) observed in oxidative stress levels between the Bridelia group and the comparator group [TBARS: 323.0 ng/L (287.5ā374.0) and 317.0 ng/L (272.5ā342.0), respectively]. Nonetheless, the Bridelia group had significantly higher antioxidant capacity (š± = 0.001) compared to the comparator group [TAC: 1.01 mmol/L (0.93ā1.10) versus 0.92 mmol/L (0.84ā1.03), respectively]. Participants in the comparator group, who did not drink Bridelia tea, had been on longer metformin treatment with better glycaemic control. However, those who drank the Bridelia tea showed comparable levels of oxidative stress and exhibited elevated antioxidant levels compared to those who did not.
šš¼š»š°š¹ššš¶š¼š»š: Bridelia tea consumption may serve as a sustainable source of antioxidants; however, its effect on mitigating oxidative stress in ILWT2D requires further investigation, particularly given that no significant improvement in TBARS was observed. Future studies are needed to clarify the potential role of Bridelia tea in oxidative stress management in resource-limited settings like Ghana.
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Keywords
šš³šŖš„š¦ššŖš¢ š§š¦š³š³š¶šØšŖšÆš¦š¢ tea, Type 2 diabetes, Oxidative stress, Antioxidants, Antioxidant-rich foods
Citation
Appiah, C. A., Ngounda, J., Boakye-Yiadom, M., Mills-Robertson, F. C., Nel, M., Johnson, R., & Walsh, C. (2025). Bridelia ferruginea tea consumption improves antioxidant status in individuals living with Type 2 Diabetes. Diabetology, 6(1), 6. https://doi.org/10.3390/diabetology6010006