The possible role of microbial proteases in facilitating SARS-CoV-2 brain invasion

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dc.contributor.authorMjokane, Nozethu
dc.contributor.authorFolorunso, Olufemi S.
dc.contributor.authorOgundeji, Adepemi O.
dc.contributor.authorSebolai, Olihile M.
dc.date.accessioned2022-08-10T12:22:28Z
dc.date.available2022-08-10T12:22:28Z
dc.date.issued2021
dc.description.abstractSARS-CoV-2 has been shown to display proclivity towards organs bearing angiotensinconverting enzyme (ACE2) expression cells. Of interest herein is the ability of the virus to exhibit neurotropism. However, there is limited information on how this virus invades the brain. With this contribution, we explore how, in the context of a microbial co-infection using a cryptococcal co-infection as a model, SARS-CoV-2 could reach the brain. We theorise that the secretion of proteases by disseminated fungal cells might also activate the S2 domain of the viral spike glycoprotein for membrane fusion with brain endothelial cells leading to endocytosis. Understanding this potential invasion mechanism could lead to better SARS-CoV-2 intervention measures, which may also be applicable in instances of co-infection, especially with protease-secreting pathogens.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.identifierhttps://doi.org/10.3390/biology10100966
dc.identifier.citationMjokane, N., Folorunso, O.S., Ogundeji, Adepemi O., & Sebolai, Olihile M. (2021). The possible role of microbial proteases in facilitating SARS-CoV-2 brain invasion. Biology, 10, 966. https://doi.org/10.3390/biology10100966en_ZA
dc.identifier.issn2079-7737
dc.identifier.urihttp://hdl.handle.net/11660/11808
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthor(s)en_ZA
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/
dc.subjectCryptococcusen_ZA
dc.subjectCo-infectionen_ZA
dc.subjectNeurotropismen_ZA
dc.subjectProteaseen_ZA
dc.subjectSARS-CoV-2en_ZA
dc.titleThe possible role of microbial proteases in facilitating SARS-CoV-2 brain invasionen_ZA
dc.typeArticleen_ZA
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