Medical Microbiology
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Taxonomy, spoilage, and virulence characteristics of Kaistella species isolated from fish
(University of the Free State, 2023)In previous studies at the University of the Free State, aerobic, Gram-negative bacteria were isolated from Cape hake (Merluccius capensis), intended for human consumption. Although some of these isolates could be identified, ... -
Evaluating the role of efflux pumps in bacterial disinfectant resistance
(University of the Free State, 2022)The global rise of antibiotic resistance could lead to the advent of a post-antibiotic era, where disinfectants and biosecurity will be vital parts to control microbial proliferation. The SARS-CoV-2 pandemic has shown how ... -
The evaluation of a continual disinfection program on a commercial broiler chicken farm
(University of the Free State, 2022)The rise of antibiotic resistance as a global health threat has been linked to overuse of antibiotics, in particular, in the agricultural sector. A post-antibiotic world is fast approaching where antibiotics may be completely ... -
Development and application of molecular assays for mosquito-borne alphaviruses in South Africa
(University of the Free State, 2021-12)Surveillance of mosquito-borne alphaviruses is critical for the prevention of diseases and the control of outbreaks caused by these viruses, especially with the absence of approved vaccines and antiviral treatments available. ... -
HBV viral load and drug resistance among HIV-HBV co-infected patients: a cross-sectional study in central South Africa
(University of the Free State, 2021-12)In South Africa, human immunodeficiency virus (HIV) infected individuals co-infected with hepatitis B virus (HBV) do not routinely undergo HBV viral load (VL) testing when on antiretroviral therapy in the public sector ... -
Whole genome analysis of rare and/or novel rotavirus strains post-Rotarix® introduction in Zambia
(University of the Free State, 2021-06)Background: Group A rotaviruses (RVA) cause acute diarrhoea in children under the age of five years. In sub-Saharan Africa, limited studies have been conducted on RVA at whole genome level, particularly post-vaccine ... -
Genetic analysis of human papillomavirus type 11 isolates from patients with recurrent respiratory papillomatosis treated at Universitas Academic Hospital
(University of the Free State, 2021-07)Human papillomavirus type 11 (HPV11) is a causative agent of recurrent respiratory papillomatosis (RRP), a common benign laryngeal neoplasm that presents mainly in children. The genome comprises three regions: the early ... -
Zoonotic diseases in high-risk populations in the Free State province, South Africa
(University of the Free State, 2021-05)Zoonotic diseases are infectious diseases transmitted from vertebrate animals to humans and are accountable for more than 60% of all recognized human diseases and 75% of all new or emerging infectious diseases (EID). In ... -
Whole-genome analyses of rotavirus strains circulating pre- and post- Rotateq™ vaccine introduction in Rwanda
(University of the Free State, 2020-09)Children living in developing countries are constantly faced with the burden of diarrheal infections that account for over 1.6 million death cases globally. Rotavirus group A (RVA) has been identified as one of the viruses ... -
Drug resistance mutations in newly diagnosed HIV-infected infants and in children and adolescents with virological failure on ART
(University of the Free State, 2020-12)Introduction and aim: South Africa has never experienced an epidemic of the same extent and magnitude as the one with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS).The roll out of ... -
The distribution, patient characteristics, therapy and patient outcome in culture positive invasive mold infections in a tertiary hospital in the Free State province, South Africa
(University of the Free State, 2019)Introduction Fungi, including molds, are increasingly recognized as important pathogens carrying a high morbidity and mortality in critically ill and immune compromised patients and our understanding of these diseases ... -
Characterization of T cell responses to the non-structural proteins of the M segment in survivors of Crimean-Congo haemorrhagic fever
(University of the Free State, 2019-02)Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV) is one of the most widely distributed arboviruses globally. The disease caused by the virus, Crimean- Congo haemorrhagic fever (CCHF), continues to emerge and re-emerge ... -
Die voorkoms van giste tydens hoenderproduksie
(University of the Free State, 2000-12)Afrikaans: Die verhoging in die plasing van die aantal hoenders per oppervlakte verhouding in moderne pluimvee boerdery praktyke, skep In klimaat waar mikrobiese groei (insluitend patogeniese mikroorganismes) gestimuleer ... -
Preparation of recombinant antigen for serological detection of African hantaviruses
(University of the Free State, 2017-07)Unlike other members of the Bunyaviridae family, hantaviruses are transmitted to humans through direct exposure or inhalation of virus contaminated urine or droppings from their reservoir hosts. Hantaviruses were first ... -
The development of a method for the detection and estimation of CCHF virus RNA in tick species
(University of the Free State, 2000-05)Crimean Congo haemorrhagic fever (CCHF), caused by a RNA virus, is a tick-borne viral zoonosis occurring in Europe, Asia and Africa. The fatality rate is ±30%. Rapid and accurate diagnosis is essential. The aim of this ... -
Evaluation of constructed recombinant mengoviruses and other HIV vaccine candidates in murine and primate models
(University of the Free State, 2001-03)The development of an effective vaccine against HIV is a formidable challenge. The overall objective of this work was to evaluate different HIV -1 vaccine approaches in primate and murine models. In a first approach ... -
Beta-lactam resistance profiles in urinary tract infection among Escherichia coli isolates in Bloemfontein
(University of the Free State, 2005-05)English: This study was designed to elucidate the epidemiology, nature and extent of β-lactam resistance in urinary tract infections caused by Escherichia coli isolates in Bloemfontein hospitals. To reach this goal it ... -
Strain characterisation, antibiotic resistance and Meca Gene analysis of Staphylococci
(University of the Free State, 1999-12)S. aureus, is undoubtedly the most pathogenic of the Staphylococcus species, having the ability to produce invasive and toxigenic infections. Historically, the less virulent coagulase-negative staphylococci (ENS) were ... -
Immunogenicity and serological applications of flavivirus ED III proteins and multiplex RT-PCR for detecting novel Southern African viruses
(University of the Free State, 2015-01)English: West Nile virus (WNV) is endemic to southern Africa but the true burden of disease associated with WNV infection remains unknown in this region. The presence of the mosquito-borne Wesselsbron virus (WESSV) has ...
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