Masters Degrees (Pharmacology)
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The role of CYP3A in nevirapine induced hepatotoxicity
(University of the Free State, 2003-11)Nevirapine is a potent non-nucleoside reverse transcriptase inhibitor with favourable pharmacokinetics that are characterised by rapid absorption and distribution with a long elimination half-life. Nevirapine is effective ... -
The effect of liposomal charge on the distrubution of liposomes to the liver, brain, lungs and kidneys in a rat model
(University of the Free State, 2003-01)English:Gentamicin was selected out of three drugs as the most appropriate liposomal marker based on its properties There after, a simple method for preparation of charged Iiposomes by rotary evaporation and hydration ... -
The pharmacokinetic interactions between valproic acid and acyclovir assessed in vitro and in a rabbit model
(University of the Free State, 2008-03)English: Valproic acid is an antiepileptic drug that is widely used for treatment of epilepsy, while acyclovir is an antiviral drug indicated for treatment of infections caused by herpes simplex type I & II and ... -
Development and validation of assay methods for the quantitative determination of drugs and their metabolites in biological specimens (piroxicam and nabumetone)
(University of the Free State, 2001-05)English: The development and validation of bioanalytical assay methods suitable for the quantitation of drugs in biological matrices is discussed, as well as general principles applicable to this particular aspect of ... -
Physical activity and lifestyle aspects of female students at a tertiary institution
(University of the Free State, 2013-07)English: BACKGROUND AND RATIONALE: It is generally believed that a sharp rise in chronic diseases and unhealthy living has occurred. Researchers believe that the modern lifestyle and a lack in physical activity (PA) are ... -
Clozapine: the correlation between clinical improvement and laboratory parameters
(University of the Free State, 1977)English: In this study, fifteen Black patients suffering from acute schizophrenia were treated with clozapine for a period of 40 days in order to ascertain whether certain laboratory parameters could be utilized to give ... -
Identification and confirmation of the presence of some steroid-like growth promoters in the urine of cattle and swine
(University of the Free State, 1998-11)English: Anabolic steroids and/or growth promoters are used to improve growth rate and feed conversion efficiency of livestock. The residues of these anabolics, which are present in the meat, may have a pharmacological ... -
Hypothalamic-pituitary-adrenal axis function and hypothalamic-pituitary-thyroid axis function in mentally retarded oatients with and without self-injurious and/or aggressive behaviour
(University of the Free State, 2003-12)English: The etiology of aggression and self-injuring behaviour in low functioning mentally retarded patients is multi-factorial and may reflect the presence of undiagnosed psychiatric conditions, unapparent due to the ... -
The development and validation of quantitative methods for the determination of stavudine and alfuzosin in plasma and monic acid in urine
(University of the Free State, 2003-05)English: The development and validation of bio-analytica) assay methods suitable for the quantification of stavudine in plasma, alfuzosin in plasma and monic acid in urine is discussed. A short summary of these methods ... -
The development and validation of assay methods for the quantitative determination of drugs and their metabolites in biological specimens: clarithromycin, carbamazepine and carbamazepine-10, 11-epoxide
(University of the Free State, 2003-05)The projects described in this dissertation use cutting edge technology to quantitate various drugs in plasma. Highly sensitive assay methods for the quantification of clarithromycin, carbamazepine and its major ... -
The effect of the traditional medicine phela on p-glycoprotein and multidrug resistance-associated protein 2 drug transporters in the gastrointestinal tract of a rat model
(University of the Free State, 2015-11)English: Phela is the herbal preparation of four African traditional medicinal plants, and is under the development by the Medical Research Council (MRC) as an immune stimulant for immune compromised individuals. Patients ... -
Factors influencing antibiotic use in the paediatric intensive care unit at Universitas Hospital from 1998 to 2007
(University of the Free State, 2013-02)English: Many antibiotics have been developed and are available on the market. An increase in the use of antibiotics in hospitals was observed and antibiotics are among the medicines most commonly prescribed to paediatric ... -
Co-morbidity of and treatment for irritable bowel syndrome, depression and anxiety in residents of retirement villages
(University of the Free State, 2014-12)Introduction: Irritable bowel syndrome (IBS), depression and anxiety are very common and often co-occur. Data for depression prevalence in the elderly in South Africa is available, but there is no data on the prevalence ... -
The effect of Phela, a traditional medicine on the immune system of a rat model
(University of the Free State, 2010-08)English: Phela is a herbal traditional medicine product prepared using well defined parts of four African medicinal plants. The aim of the study was to determine the mechanism of action by which phela boosted the immune ... -
Evaluation of grapefruit extract for the prevention of paracetamol-induced hepatotoxicity after overdose in rats
(University of the Free State, 2015-05)English: Paracetamol is a widely used analgesic and antipyretic agent. While it is generally safe for use at recommended doses, acute overdose of paracetamol can cause potentially fatal liver damage. Despite the understanding ... -
Cytochrome P450 and the immune response to prolonged administration of isoniazid, nevirapine and paracetamol in a rat model
(University of the Free State, 2015-02)English: Drug-induced liver injury is a major adverse drug reaction that presents during isoniazid (INH) and nevirapine (NVP) treatment, and after paracetamol (PAR) overdose. It was postulated that after these drugs are ... -
The simultaneous detection of narcotic analgesics and non-steroidal anti-inflammatory drugs in human urine using high performance liquid chromatography - tandem mass spectrometry
(University of the Free State, 2009)The use of over-the-counter products (OTCs) has increased over the years. This is evident from the wide range of products available and also the easy availability of these OTCs in pharmacies, health shops and even supermarkets ...
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