Research Articles (Haematology and Cell Biology)

The use of topical crushed tranexamic acid tablets to control bleeding after dental surgery and from skin ulcers in haemophilia

Coetzee, M. J. (Wiley, 2007)

Screening for calreticulin mutations in a cohort of patients suspected of having a myeloproliferative neoplasm

De Kock, A.; Booysen, C. (Health and Medical Publishing Group (HMPG), 2016)

Background. The discovery of calreticulin (CALR) has shown it to be the second most frequent mutation after the Janus Kinase 2 (JAK2) mutation in myeloproliferative neoplasms (MPNs). Its structure indicates various ...

Laboratory diagnosis and management of von Willebrand disease in South Africa

Meiring, Muriel; Coetzee, Marius; Kelderman, Mareli; Badenhorst, Philip (Thieme Medical Publishers, 2011)

Patients with von Willebrand disease (VWD) in South Africa are cared for in 17 Hemophilia Treatment Centers. The exact prevalence of the disease is uncertain, but 539 patients are annotated in registries. VWD patients ...

Phase I, randomized, double-blind, placebo-controlled, single-dose escalation study of the recombinant factor VIIa variant BAY 86-6150 in hemophilia

Mahlangu, J. N.; Coetzee, M. J.; Laffan, M.; Windyga, J.; Yee, T. T.; Schroeder, J.; Haaning, J.; Siegel, J. E.; Lemm, G. (International Society on Thrombosis and Haemostasis, 2012)

Background: BAY 86-6150 is a new human recombinant factor VIIa variant developed for high procoagulant activity and longer action in people with hemophilia with inhibitors. Objectives: To investigate the safety, ...

A case study of GM maize gene flow in South Africa

Viljoen, Chris; Chetty, Lukeshni (Springer, 2011)

Background: South Africa has been growing first-generation commercial genetically modified (GM) maize since 1997. Despite a requirement for non-GM food, especially for export, there is no system for coexistence of GM ...

Differential sensitivity of von Willebrand factor (VWF) 'activity' assays to large and small VWF molecular weight forms: a cross-laboratory study comparing ristocetin cofactor, collagen-binding and mAb-based assays

Favaloro, E. J.; Bonar, R.; Chapman, K.; Meiring, M.; Funk, D. (International Society on Thrombosis and Haemostasis, 2012)

Background: von Willebrand disease (VWD), the most common inherited bleeding disorder, is caused by deficiencies and/or defects in von Willebrand factor (VWF). An effective diagnostic and VWD typing strategy requires plasma ...

Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines

Chen, Weikai; Leiter, Amanda; Yin, Dong; Meiring, Muriel; Louw, Vernon J.; Koeffler, H. Phillip (Spandidos Publications, 2010)

Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer with a substantial risk of metastasis which causes clinical treatment failure. This study investigated the anti-CSCC effects of a triterpenoid ...