Doctoral Degrees (Haematology and Cell Biology)
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Characterisation of the fibrinolytic system and the Von Willebrand factor-Adamts13 axis in the Chacma baboon
(University of the Free State, 2021-11)Background: The Chacma baboon (Papio ursinus) model of acquired thrombotic thrombocytopenic purpura (aTTP) is ideally suited to investigate novel treatments with potential application in this lethal thrombotic disorder, ... -
Haemostatic and thrombotic disorders: a journey from bench to bedside
(University of the Free State, 2019-12)This compilation focuses on thrombotic and haemostatic disorders, illustrating my journey from basic research on thrombotic and haemostatic disorders to the differential diagnoses of these disorders. For purposes of clarity ... -
Telomeres and telomerase in cancer of esophagus
(University of the Free State, 2001-11)English: Squamous cell carcinoma of the esophagus is a cancer with a high incidence in South Africa. We have investigated the prognostic value of telomerase activity in tumors as well as in nearby normal tissue. Biopsies ... -
Recombinant production and evaluation of a multifunctional haemostatic fusion protein
(University of the Free State, 1999-10)Platelets and coagulation both play a pivotal role in thrombosis, one of the major life-threatening diseases in our society. We have thus experienced a drastic increase in the development of potent and secure ... -
Phage display selection of peptide inhibitors of FVIIa and their functional characterisation
(University of the Free State, 2002-06)English: The importance of FVlla and the FVlla/TF complex for the initiation of not only hemostasis but also thrombosis is now generally accepted. It was shown that the blockade of coagulation at the level of FVlla ... -
Comparison of platelet receptors P2Y12, GPIIB/IIIA, GPVI, and GPIBα between the Cape chacma baboon and the human
(University of the Free State, 2015)English: Background: Acute coronary syndrome is globally a major cause of morbidity and mortality. Treatment and prevention involve the use of an anti-platelet agent. The current available agents have either side-effects ... -
Monitoring of genetically modified food products in South Africa
(University of the Free State, 2010-12)English: Globally, South Africa is the eighth largest producer of GM crops and also imports GM food. In addition to the promise of increased agricultural production, the introduction of GM crops is also having an impact ...
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