English: This contribution examines the TB- and HIV/AIDS-related health promotion materials currently in use in the Free State (South Africa) and in Lesotho. It first considers the cultural implications of choosing various visual and verbal design elements in a health-related message. It then analyses a number of health promotion posters on the basis of research findings and the general principles of message design in a multicultural context. Finally, a visual essay approach is taken, commenting on the roadside billboards and alternative health promotion media encountered in the Free State and Lesotho.