Now showing items 1-4 of 4
The pharmacokinetic interactions between valproic acid and acyclovir assessed in vitro and in a rabbit model
(University of the Free State, 2008-03)
English: Valproic acid is an antiepileptic drug that is widely used for treatment of epilepsy, while acyclovir is an antiviral drug indicated for treatment of infections caused by herpes simplex type I & II and ...
The simultaneous detection of narcotic analgesics and non-steroidal anti-inflammatory drugs in human urine using high performance liquid chromatography - tandem mass spectrometry
(University of the Free State, 2009)
The use of over-the-counter products (OTCs) has increased over the years. This is evident from the wide range of products available and also the easy availability of these OTCs in pharmacies, health shops and even supermarkets ...
The effect of the traditional medicine phela on p-glycoprotein and multidrug resistance-associated protein 2 drug transporters in the gastrointestinal tract of a rat model
(University of the Free State, 2015-11)
English: Phela is the herbal preparation of four African traditional medicinal plants, and is under the development by the Medical Research Council (MRC) as an immune stimulant for immune compromised individuals. Patients ...
Evaluation of grapefruit extract for the prevention of paracetamol-induced hepatotoxicity after overdose in rats
(University of the Free State, 2015-05)
English: Paracetamol is a widely used analgesic and antipyretic agent. While it is generally safe for use at recommended doses, acute overdose of paracetamol can cause potentially fatal liver damage. Despite the understanding ...