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Immune responses to Crimean-Congo haemorrhagic fever virus and molecular characterization of viral isolates
(University of the Free State, 2014-02)
Crimean-Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus belonging to the family Bunyaviridae, genus Nairovirus. The distribution of the virus correlates with that of the principal vector, ticks belonging to ...
Evaluation of constructed recombinant mengoviruses and other HIV vaccine candidates in murine and primate models
(University of the Free State, 2001-03)
The development of an effective vaccine against HIV is a formidable challenge. The overall
objective of this work was to evaluate different HIV -1 vaccine approaches in primate and
murine models. In a first approach ...
Whole-genome analyses of rotavirus strains circulating pre- and post- Rotateq™ vaccine introduction in Rwanda
(University of the Free State, 2020-09)
Children living in developing countries are constantly faced with the burden of diarrheal infections that account for over 1.6 million death cases globally. Rotavirus group A (RVA) has been identified as one of the viruses ...
Drug resistance mutations in newly diagnosed HIV-infected infants and in children and adolescents with virological failure on ART
(University of the Free State, 2020-12)
Introduction and aim: South Africa has never experienced an epidemic of the same extent and magnitude as the one with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS).The roll out of ...
Immunogenicity and serological applications of flavivirus ED III proteins and multiplex RT-PCR for detecting novel Southern African viruses
(University of the Free State, 2015-01)
English: West Nile virus (WNV) is endemic to southern Africa but the true burden of disease associated with WNV infection remains unknown in this region. The presence of the mosquito-borne Wesselsbron virus (WESSV) has ...