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Isolation of bioactive constituents from seeds of Schotia brachypetala (Fabaceae) and Colophospermum mopane (Fabaceae)
(University of the Free State, 2011-11)
Natural products play an important role in drug discovery, as scaffolds and new skeletons. It is remarkable to note that in 2007, natural products were implicated in the development of 52% of all new drugs. These compounds ...
Hplc-based activity profiling for hERG channel inhibitors from Galenia africana and Gnidia polycephala, and counter-current chromatographic isolation of antimicrobials from Colophospermum mopane
(University of the Free State, 2015-01)
The human ether-a-go-go-related gene (hERG) channel plays a critical role in cardiac action potential repolarization. Blocking of the channel by drugs may lead to a fatal type of arrhythmia, named “torsades de pointes” ...