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dc.contributor.advisorBadenhorst, P. N.
dc.contributor.authorKotze, Herculaas Frederik
dc.date.accessioned2018-03-22T10:33:02Z
dc.date.available2018-03-22T10:33:02Z
dc.date.issued2000-07
dc.identifier.urihttp://hdl.handle.net/11660/8059
dc.description.abstractThis synopsis focuses primarily on platelet kinetics, the role of platelets in thrombosis and the effect of inhibition of platelet function on thrombosis. It highlights our contribution to these fields of study. Key references are given as footnotes. Our own publications are cited in parentheses. For purposes of clarity, the publications are grouped under three headings. Those in the first group deal with the methods that we developed to isolate a representative and viable population of platelets from blood, to effectively label them with In-Ill and to accurately quantify their in vivo distribution. They also address normal platelet kinetics and explain what information can be deducted from kinetic studies. Those in the second group describe how we used In-Ill-platelets as an investigative tool to study various aspects of platelet function utilising several approaches in patients and experimental animals. Those in the third group describe our contribution to assess the effective use of agents developed to inhibit specific components of the thrombotic process.en_ZA
dc.language.isoenen_ZA
dc.publisherUniversity of the Free Stateen_ZA
dc.subjectBlood plateletsen_ZA
dc.subjectThrombosisen_ZA
dc.subjectThesis (D.Sc. (Haematology and Cell Biology))--University of the Free State, 2000en_ZA
dc.titlePlatelet kinetics and thrombogenesisen_ZA
dc.typeThesisen_ZA
dc.rights.holderUniversity of the Free Stateen_ZA


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