Cardiothoracic Surgery
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Impact of three different processing techniques on the strength and structure of juvenile pulmonary homografts
(MDPI, 2022)Homografts are routinely stored by cryopreservation; however, donor cells and remnants contribute to immunogenicity. Although decellularization strategies can address immunogenicity, additional fixation might be required ... -
Critical analysis of rheumatic mitral valve surgery outcomes in central South Africa
(University of the Free State, 2021-10)Introduction: Rheumatic heart disease (RHD) is still an important cause of acquired heart disease affecting children and young adults from poor socio-economic backgrounds. The most common presentation of RHD is mitral valve ... -
Infective endocarditis in central South Africa in the HIV era- a surgical perspective
(University of the Free State, 2021-03)Introduction: Infective endocarditis (IE) remains an evolving disease with a persistently high mortality and morbidity. In Africa, it is predominantly a disease of the young in contrast to the developed world. South Africa ... -
Processed pulmonary homografts in the right ventricle outflow tract: an experimental study in the juvenile ovine model
(University of the Free State, 2020-02)The availability of pulmonary homografts with improved biomechanical properties, tissue stability, reduced calcification and improved durability for right ventricular outflow tract (RVOT) reconstruction is desired. In ... -
The impact of extended harvesting times on tissue integrity of cryopreserved ovine pulmonary homograts
(University of the Free State, 2017-02)English: The use of aorta valve homografts in cardiac surgery was pioneered by Donald Ross and Barratt-Boyes (Ross, 1962; Barratt-Boyes, 1964) and today, pulmonary valve homografts remain the valved conduit of choice for ... -
Hydrodynamic and coagulation characteristics of a re-engineered mechanical heart valve in an ovine model
(University of the Free State, 2017-01)Introduction A valve with haemodynamic properties mimicking a natural heart valve and having the durability that will exceed the life expectancy of the recipient patient without requiring lifelong anti-coagulation, would ...
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