• The evaluation of a continual disinfection program on a commercial broiler chicken farm 

  Beauzec, Deon (University of the Free State, 2022)

  The rise of antibiotic resistance as a global health threat has been linked to overuse of antibiotics, in particular, in the agricultural sector. A post-antibiotic world is fast approaching where antibiotics may be completely ...

• Evaluating the role of efflux pumps in bacterial disinfectant resistance 

  Staats, Gunther Johann (University of the Free State, 2022)

  The global rise of antibiotic resistance could lead to the advent of a post-antibiotic era, where disinfectants and biosecurity will be vital parts to control microbial proliferation. The SARS-CoV-2 pandemic has shown how ...

• Development and application of molecular assays for mosquito-borne alphaviruses in South Africa 

  Dimaculangan, Micah (University of the Free State, 2021-12)

  Surveillance of mosquito-borne alphaviruses is critical for the prevention of diseases and the control of outbreaks caused by these viruses, especially with the absence of approved vaccines and antiviral treatments available. ...

• HBV viral load and drug resistance among HIV-HBV co-infected patients: a cross-sectional study in central South Africa 

  Kotze, Jacobus Charles (University of the Free State, 2021-12)

  In South Africa, human immunodeficiency virus (HIV) infected individuals co-infected with hepatitis B virus (HBV) do not routinely undergo HBV viral load (VL) testing when on antiretroviral therapy in the public sector ...

• Whole genome analysis of rare and/or novel rotavirus strains post-Rotarix® introduction in Zambia 

  Maringa, Wairimu Makena (University of the Free State, 2021-06)

  Background: Group A rotaviruses (RVA) cause acute diarrhoea in children under the age of five years. In sub-Saharan Africa, limited studies have been conducted on RVA at whole genome level, particularly post-vaccine ...

• Genetic analysis of human papillomavirus type 11 isolates from patients with recurrent respiratory papillomatosis treated at Universitas Academic Hospital 

  Thuynsma, Corne (University of the Free State, 2021-07)

  Human papillomavirus type 11 (HPV11) is a causative agent of recurrent respiratory papillomatosis (RRP), a common benign laryngeal neoplasm that presents mainly in children. The genome comprises three regions: the early ...

• Zoonotic diseases in high-risk populations in the Free State province, South Africa 

  Van der Westhuizen, Cornelius Gerhardus (University of the Free State, 2021-05)

  Zoonotic diseases are infectious diseases transmitted from vertebrate animals to humans and are accountable for more than 60% of all recognized human diseases and 75% of all new or emerging infectious diseases (EID). In ...

• Whole-genome analyses of rotavirus strains circulating pre- and post- Rotateq™ vaccine introduction in Rwanda 

  Rasebotsa, Sebotsana Paula (University of the Free State, 2020-09)

  Children living in developing countries are constantly faced with the burden of diarrheal infections that account for over 1.6 million death cases globally. Rotavirus group A (RVA) has been identified as one of the viruses ...

• The distribution, patient characteristics, therapy and patient outcome in culture positive invasive mold infections in a tertiary hospital in the Free State province, South Africa 

  Van der Westhuizen, B. (University of the Free State, 2019)

  Introduction Fungi, including molds, are increasingly recognized as important pathogens carrying a high morbidity and mortality in critically ill and immune compromised patients and our understanding of these diseases ...

• Characterization of T cell responses to the non-structural proteins of the M segment in survivors of Crimean-Congo haemorrhagic fever 

  Maotoana, Makgotso Golda (University of the Free State, 2019-02)

  Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV) is one of the most widely distributed arboviruses globally. The disease caused by the virus, Crimean- Congo haemorrhagic fever (CCHF), continues to emerge and re-emerge ...

• Die voorkoms van giste tydens hoenderproduksie 

  Laubscher, Willem Diederik Froneman (University of the Free State, 2000-12)

  Afrikaans: Die verhoging in die plasing van die aantal hoenders per oppervlakte verhouding in moderne pluimvee boerdery praktyke, skep In klimaat waar mikrobiese groei (insluitend patogeniese mikroorganismes) gestimuleer ...

• Preparation of recombinant antigen for serological detection of African hantaviruses 

  Damane, Deborah Rethabile (University of the Free State, 2017-07)

  Unlike other members of the Bunyaviridae family, hantaviruses are transmitted to humans through direct exposure or inhalation of virus contaminated urine or droppings from their reservoir hosts. Hantaviruses were first ...

• The development of a method for the detection and estimation of CCHF virus RNA in tick species 

  Du Preez, Patrick Hendrik (University of the Free State, 2000-05)

  Crimean Congo haemorrhagic fever (CCHF), caused by a RNA virus, is a tick-borne viral zoonosis occurring in Europe, Asia and Africa. The fatality rate is ±30%. Rapid and accurate diagnosis is essential. The aim of this ...

• Beta-lactam resistance profiles in urinary tract infection among Escherichia coli isolates in Bloemfontein 

  Maqutu, Lennox Makhelane (University of the Free State, 2005-05)

  English: This study was designed to elucidate the epidemiology, nature and extent of β-lactam resistance in urinary tract infections caused by Escherichia coli isolates in Bloemfontein hospitals. To reach this goal it ...

• Strain characterisation, antibiotic resistance and Meca Gene analysis of Staphylococci 

  Vorster, Alvera (University of the Free State, 1999-12)

  S. aureus, is undoubtedly the most pathogenic of the Staphylococcus species, having the ability to produce invasive and toxigenic infections. Historically, the less virulent coagulase-negative staphylococci (ENS) were ...

• Preparation and immunogenicity of a candidate replicon based yellow fever vaccine 

  Viljoen, Natalie (University of the Free State, 2014-12)

  English: Yellow fever virus (YFV), a mosquito-borne virus that belongs to the family Flaviviridae and genus Flavivirus, is a significant cause of morbidity and mortality in yellow fever endemic areas, especially in West ...

• Molecular epidemiology of Mycobacterium tuberculosis strains from the Free State and Northern Cape provinces, South Africa 

  Mokhethi, Sehloho Zacharia (University of the Free State, 2004-05)

  Background. Tuberculosis is increasing in the Free State and Northern Cape provinces of South Africa, but it is not clear how much of the disease is caused by reactivated latent infection and how much is attributed to ...

• Identification of antigenic regions and linear B cell epitopes on yellow fever virus 

  Smouse, Shannon Lucrecia (University of the Free State, 2013-02)

  English: Yellow fever virus (YFV) virus is an arthropod-borne virus that causes viral hemorrhagic fever in humans in the tropical parts of both Africa and South America. The virus belongs to the family Flaviviridae, of the ...

• Identification of antigen-specific serological cross-reactivity among survivors of Crimean-Congo Haemorrhagic fever 

  Rangunwala, Azeeza (University of the Free State, 2013)

  Abstract not available

• Development of molecular and serological assays for diagnosis and surveillance of Crimean-Congo haemorrhagic fever virus 

  Pieters, Danelle (University of the Free State, 2015-05)

  Crimean-Congo haemorrhagic fever virus (CCHFV) an arthropod-borne virus associated with haemorrhagic disease in humans. The global distribution of CCHFV correlates with that of ticks from the Hyalomma genus. CCHFV infection ...

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