Microbial, Biochemical and Food Biotechnology
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Rotavirus-mediated prostaglandin E2 production in MA104 cells promotes virus attachment and internalisation, resulting in an increased viral load
(Frontiers Media, 2022)Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known ... -
The possible role of microbial proteases in facilitating SARS-CoV-2 brain invasion
(MDPI, 2021)SARS-CoV-2 has been shown to display proclivity towards organs bearing angiotensinconverting enzyme (ACE2) expression cells. Of interest herein is the ability of the virus to exhibit neurotropism. However, there is limited ... -
Genetic characterisation of South African and Mozambican bovine rotaviruses reveals a typical bovine-like artiodactyl constellation derived through multiple reassortment events
(MDPI, 2021)This study presents whole genomes of seven bovine rotavirus strains from South Africa and Mozambique. Double-stranded RNA, extracted from stool samples without prior adaptation to cell culture, was used to synthesise cDNA ... -
Bioflocculant produced by Bacillus velezensis and its potential application in brewery wastewater treatment
(Scientific Reports, 2022-06)This study was designed to evaluate the potential of bioflocculant producing strains isolated from wastewater sludge. According to the Plackett–Burman design, the response surface revealed glucose, magnesium sulfate, and ... -
Pathogenic potential and control of Chryseobacterium species from clinical, fish, food and environmental sources
(MDPI, 2022)Chryseobacterium species are isolated and taxonomically evaluated from a wide range of sources. While C. gleum and C. indologenes have been implicated in human disease, the potential pathogenicity of numerous other species ... -
Classification and spoilage characteristics of Chryseobacterium isolates from fish
(University of the Free State, 2019)The genus Chryseobacterium was initially reported to have only six species and the number has increased rapidly over the years. The genus is represented by a total of 113 species at present. Species belonging to the genus ... -
Recent advances and opportunities in the study of Candida albicans polymicrobial biofilms
(Frontiers, 2022)It is well known that the opportunistic pathogenic yeast, Candida albicans, can form polymicrobial biofilms with a variety of bacteria, both in vitro and in vivo, and that these polymicrobial biofilms can impact the course ... -
Cryptococcal protease(s) and the activation of SARS-CoV-2 spike (S) protein
(MDPI, 2022)In this contribution, we report on the possibility that cryptococcal protease(s) could activate the SARS-CoV-2 spike (S) protein. The S protein is documented to have a unique four-amino-acid sequence (underlined, SPRRAR|S) ... -
The repurposing of acetylsalicylic acid as a photosensitiser to inactivate the growth of cryptococcal cells
(MDPI, 2021)Photodynamic treatment (PDT) is often successful when used against aerobic microbes, given their natural susceptibility to oxidative damage. To this end, the current study aimed to explore the photodynamic action of ... -
Fusarium casha sp. nov. and F. curculicola sp. nov. in the Fusarium fujikuroi species complex isolated from Amaranthus cruentus and three weevil species in South Africa
(MDPI, 2021)Trials are currently being conducted in South Africa to establish Amaranthus cruentus as a new pseudocereal crop. During recent surveys, Fusarium species were associated with weevil damage in A. cruentus fields. Preliminary ... -
Risk factors for fungal co-infections in critically ill COVID-19 patients, with a focus on immunosuppressants
(MDPI, 2021)Severe cases of coronavirus disease 2019 (COVID-19) managed in the intensive care unit are prone to complications, including secondary infections with opportunistic fungal pathogens. Systemic fungal co-infections in ... -
The development of a CRISPR-Cas9 gene editing system for Cryptococcus deneoformans
(University of the Free State, 2019-01)The pathogenic yeasts, Cryptococcus neoformans and C. deneoformans, are responsible for potentially fatal meningoencephalitis in immunocompromised individuals, most notably in patients who have AIDS. Only three drugs are ... -
Studying the regulation of immune signalling molecules related to immunity during Avibacterium paragallinarum infection
(University of the Free State, 2019-06)Infectious coryza is a contagious and acute upper respiratory poultry disease caused by Avibacterium paragallinarum, that plagues predominantly layers but also affects broiler breeds. The chicken’s immune response to Av. ... -
The development of a wide range CRISPR-Cas9 gene editing system
(University of the Free State, 2019-01)CRISPR is a revolutionary method to effectively and efficiently alter the genomic make-up of an organism. Unlike any other genetic engineering tool or technique, CRISPR is remarkably cheaper, simpler and faster to perform. ... -
Antibody fragments as a possible therapeutic treatment for infectious bronchitis in poultry
(University of the Free State, 2018-09)Infectious bronchitis virus (IBV), a coronavirus, is the etiological agent for infectious bronchitis (IB), an acute respiratory disease of poultry. Infectious bronchitis is a notifiable disease, and taking in consideration ... -
The production of 3-hydroxy fatty acids by the yeast Dipodascopsis uninucleata and its implications
(University of the Free State, 1999-11)English: In 1991, a novel eicosanoid namely 3-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (3-HETE) was uncovered in the yeast Dipodascopsis uninucleata by van Dyk and co-workers. Strikingly, the production of this compound ... -
Changes in microbial ecology during poultry production
(University of the Free State, 2000-03)Microorganisms, especially pathogens, play an important role in the deterioration of poultry meat and its products causing spoilage or food poisoning. The meat renders an ideal medium for the growth and progression of ... -
Determining the canning quality of small seeded white beans (Phaseolus vulgaris L.)
(University of the Free State, 1999-05)English: It is important to the producers, processors and consumers in south Africa to have dry bean cultivars with acceptable canning quality. Therefore, dry bean breeders needs sui table screening methods to evaluate ... -
The utilisation of used and other fats by fungi
(University of the Free State, 2000-09)English: In 1997, Jeffery and co-workers discovered that when Mucor circinelloides t. circinelloides CBS 108.16 was cultivated on 30g/1 sunflower oil and 10g/1 sodium acetate, an improved utilisation of the oil, doubling ... -
Mucoralean fungi present in soil from arid regions in South Africa
(University of the Free State, 1999-11)English: The aim of the first part of the study was to investigate the ecological niche of mucoralean fungi in arid soil, with specific reference to the position these fungi occupy in the biogeochemical cycle of nitrogen. ...
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