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An investigation into the efflux mechanism against quaternary ammonium compounds as a contribution of bacterial resistance
(University of the Free State, 2014-01)
Bacterial infections, a major problem in the poultry industry, are controlled through the use of antibiotics. Due to the increase in antibiotic resistance and the restrictions placed on the use of antibiotics in animals, ...
The development of a molecular serotyping system and an investigation into the presence of prophages in Avibacterium paragallinarum serogroups
(University of the Free State, 2014-01)
Avibacterium paragallinarum is an avian pathogen that causes the upper respiratory disease Infectious coryza (IC) in chickens. This disease has the ability to cause vast economic losses due to a decrease in egg production. ...
Improving the current diagnostic strategy for beak and feather disease virus in parrots
(University of the Free State, 2014)
English: Beak and feather disease (BFD), caused by Beak and feather disease virus (BFDV) is a dermatological condition afflicting parrot species. It is becoming increasingly difficult to ignore not only the significant ...
Characterization of the Baeyer-Villiger monooxygenase MoxY and closely-related homologues from Aspergillus flavus
(University of the Free State, 2014-02)
Aflatoxins are carcinogenic mycotoxins produced by certain species of the Aspergilli, with the most prominent producers being Aspergillus flavus and A. parasiticus. Exposure to aflatoxins causes liver cancer, immune ...
Exploring carbon cycling in selected micro-organisms exposed to terrestrial carbon sequestration
(University of the Free State, 2014-02)
South Africa‘s economy is primarily driven by the utilization of coal to provide electricity, which results in more fossil fuels to be burnt that contributes towards global warming. The average daily temperature is estimated ...
The Genome-wide nucleosome positions in Trypanosoma brucei procyclic and Bloodstream forms
(University of the Free State, 2014-01)
English: The epigenome represents a major regulatory interface to the eukaryotic genome. Nucleosome positions, histone variants, histone modifications and chromatin associated proteins all play a role in the epigenetic ...
A proteomic study of African elephant milk: inter-species comparisons and proteome dynamics
(University of the Free State, 2014-01)
Milk is a complex and complete food for the specific nutritional requirements of the neonate. For the dairy industry, milk is a suitable raw material for the production of other high value products. Although extensive ...
Heterologous expression of extracellular proteins by Yarrowia lipolytica
(University of the Free State, 2014-06)
English: The C. fumago chloroperoxidase (CPO) and human Granulocyte-Colony Stimulating Factor (hG-CSF) proteins require post-translation glycosylation modifications, contain intra molecular disulfide bonds for proper folding ...
Heterologous expression of cytochrome P450 monooxygenases from Aspergillus terreus and Cryptococcus neoformans
(University of the Free State, 2014-06)
English: Cytochrome P450 monooxygenases (CYP450) are heme-thiolate proteins which are present in all biological kingdoms. They catalyse the addition of a single oxygen atom to a non-activated carbon atom. The metabolic ...
Effect of cultivation conditions on heterologous expression of oxidoreductases by the yeast Blastobotrys adeninivorans
(University of the Free State, 2014-07)
English: Different oxidoreductases are being investigated for hydroxylation reactions to satisfy the global need for environmentally friendly industrial processes. These enzymes are found in microorganisms, animals and ...