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Direct synthesis of pterocarpans via aldol condensation
(University of the Free State, 2000-05)
English: Pterocarpans, representing the second largest group of natural isoflavonoids, have
received considerable interest on account of their medicinal properties over the last few
years. These phytoalexins not only ...
Studies directed at the stereoselective synthesis of flavonoids through the hydrogenation of prochiral precursors
(University of the Free State, 2008-11)
English: The in vitro studies of biologically active flavonoids are hampered by the inaccessibility of all monomeric units in enantiomerically pure form. Although a number of these scalemic flavonoids can be obtained ...
Conformational analysis of oligomeric profisetinidins
(University of the Free State, 2007-02)
English: The profisetinidins are an important class of condensed tannins, or proanthocyanidins.
Historically, studies towards the structure and conformation of proanthocyanidins were done
on their peracetate and permethyl ...
Structure and synthesis of a novel homoisoflavanone from Scilla natalensis and synthesis of selected procyanidins through the C-4 functionalization of flavan-3-ols
(University of the Free State, 2008-05)
English: Scilla natalensis planch (Hyacinthaceae), commonly known as Wild squill, Blue squill, Blue hyacinth, Blouberglelie, Blouslangkop, Inguduza, is one of the plants that are widely used in traditional medicines and ...
Development of methodology for the synthesis of 4-arylflavan-3-ol lactones
(University of the Free State, 2008-05)
English: The phenolic content of the heartwood of Peltophorum africanum (African wattle) and Burkea africanum (Red syringa) proved to contain a variety of compounds including the novel 4-arylflavan-3-ol lactones, ...
Photochemistry of (+)-catechin and (-)-epicatechin
(University of the Free State, 2008-01)
Despite the well known fact that photolysis of free phenolic catechins give rise to isomerisation at the C-2 position (e.g. (-)-cis epicatechin converts to the sterically less hindered (-)-trans isomer), researchers have ...
Development of a viable protocol aimed at the synthesis of a selected natural product with possible application in the industry
(University of the Free State, 2007)
Since the introduction of synthetic analogues in both the health-related and cosmetic industry, a new generation has emerged in search of beneficial bioactivity compounds. This generation of “natural and green” focuses ...
The structure and synthesis of oligoflavanoids and oligostilbenes from cassia abbreviata
(University of the Free State, 2000-01)
English: During the present study the acetone extract of the heartwood of Cassia abbreviata
afforded the known flavan-f-ols, catechin, epicatechin, epiafzelechin, afzelechin and the
new (2R,3S) guibourtinidol. This was ...
Epimesquitol-flavone dimers and related oligomers from Acacia nigrescens synthesis of 3',4',7,8-substituted flavonoid monomers
(University of the Free State, 2001-11)
English: The previous investigation, by Fourie in the 1970's, revealed the presence of phenolic compounds in the heartwood of Knobwood (Acacia nigrescens), comprising a series of leucomelacacinidins. Early suggestions that ...
The structure and synthesis of trimeric and related dimeric Proteracacinidins from Acacia heteroensis.
(University of the Free State, 2002-07)
English: The presence of 4', 7,8-trihydroxyl substituted flavanoids in plant material is limited to Acacia galpinii and Acacia caffra in Southern Africa. The existence of pyrogallol-type A-ring oligomers in these trees was ...