Now showing items 1-3 of 3
The effect of inflammatory cytokines and coagulation factors on Von Willebrand factor synthesis and cleavage
(University of the Free State, 2012-02)
When injured, endothelial cells secrete inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-α (TNF-α). These inflammatory cytokines stimulate the endothelial release of ...
Sequensing of exon 28 of Von Willebrand factor in five patients with type 2 Von Willebrand disease
(University of the Free State, 2009-05)
English: Von Willebrand disease (VWD) is a common bleeding disorder caused by either quantitative (type1 and 3) or qualitative (type 2) defects of von Willebrand factor (VWF). The diagnosis of VWD usually requires a panel ...
Comparison of ADAMTS13 and Von Willebrand factor antigen levels and activities and plasminogen levels, in the currently available plasma products for the treatment of thrombotic thrombocytopenic purpura in South Africa
(University of the Free State, 2018)
Thrombotic thrombocytopenic purpura results from a deficiency in the Von Willebrand factor cleaving protease, ADAMTS13. Treatment involves plasma exchange therapy with either fresh frozen plasma, cryosupernatant, or ...