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Now showing items 21-27 of 27
A yeast-based assay for detection of mutations in the human p16 gene
(University of the Free State, 1999-05)
Cyclin-dependent kinases (CDKs) are crucial regulators of the cell cyele. CDKs
themselves are subject to control by both cyelins and CDK inhibitors. Among the
inhibitors, p 16 is very prominent, since it has been found ...
Screening black South African females with Type 2 Diabetes Mellitus for mutations in the peroxisome proliferator-activated receptor gamma gene
(University of the Free State, 2016-01)
English: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder which is caused by a combination of an inadequate response to insulin secretion and a resistance to insulin action. The peroxisome proliferator-activated ...
Screening for genetic variants implicated in monogenic forms of hypertension in a hypertensive urban black Free State cohort
(University of the Free State, 2016-02)
English: Non-communicable diseases (NCDs), also known as chronic diseases of lifestyle, are
the leading cause of death worldwide. Amongst the risk factors for NCDs, hypertension
(blood pressure (BP) ≥140/90 mmHg) is one ...
Thrombogenecity of decellularized and re-endothelialized baboon arteries
(University of the Free State, 2015-02)
English: The use of decellularized biological scaffolds for the reconstruction of small-diameter (< 6 mm) vascular grafts has been the focus of tissue engineering studies. These biological materials constructed through ...
Development and application of a real-time PCR method to detect selected single nucleotide polymorphisms associated with hypertension in a black South African population
(University of the Free State, 2014-08)
English: Hypertension is one of the leading causes of death and disability in the world. In
95% of individuals with hypertension, the condition arises from the interaction of
multiple environmental factors with physiological ...
Molecular screening of the South African Indian population for BRCA1 and BRCA2 using high resolution melting analysis
(University of the Free State, 2016-01)
English: The lifetime risk for developing breast cancer within the Indian population of South Africa is one in 17. Disease causing mutations in BRCA1/2 increase the risk of developing this disease by up to 80%. The main ...
Comparison of ADAMTS13 and Von Willebrand factor antigen levels and activities and plasminogen levels, in the currently available plasma products for the treatment of thrombotic thrombocytopenic purpura in South Africa
(University of the Free State, 2018)
Thrombotic thrombocytopenic purpura results from a deficiency in the Von Willebrand factor cleaving protease, ADAMTS13. Treatment involves plasma exchange therapy with either fresh frozen plasma, cryosupernatant, or ...