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Now showing items 21-27 of 27
Screening black South African females with Type 2 Diabetes Mellitus for mutations in the peroxisome proliferator-activated receptor gamma gene
(University of the Free State, 2016-01)
English: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder which is caused by a combination of an inadequate response to insulin secretion and a resistance to insulin action. The peroxisome proliferator-activated ...
Molecular screening of the South African Indian population for BRCA1 and BRCA2 using high resolution melting analysis
(University of the Free State, 2016-01)
English: The lifetime risk for developing breast cancer within the Indian population of South Africa is one in 17. Disease causing mutations in BRCA1/2 increase the risk of developing this disease by up to 80%. The main ...
Comparison of ADAMTS13 and Von Willebrand factor antigen levels and activities and plasminogen levels, in the currently available plasma products for the treatment of thrombotic thrombocytopenic purpura in South Africa
(University of the Free State, 2018)
Thrombotic thrombocytopenic purpura results from a deficiency in the Von Willebrand factor cleaving protease, ADAMTS13. Treatment involves plasma exchange therapy with either fresh frozen plasma, cryosupernatant, or ...
A yeast-based assay for detection of mutations in the human p16 gene
(University of the Free State, 1999-05)
Cyclin-dependent kinases (CDKs) are crucial regulators of the cell cyele. CDKs
themselves are subject to control by both cyelins and CDK inhibitors. Among the
inhibitors, p 16 is very prominent, since it has been found ...
Molecular screening for the presence of large deletions or duplications in BRCA using Multiplex ligation-dependent probe amplification in South Africa
(University of the Free State, 2016-07)
English: Germline BRCA gene mutations are associated with hereditary breast and ovarian cancers (OVC). Identification of these mutations greatly improves the preventive strategies and management of patients affected with ...
Investigating the genetic profile of the E-cadherin gene in squamous carcinoma of the esophagus
(University of the Free State, 2003-06)
Thrombogenecity of decellularized and re-endothelialized baboon arteries
(University of the Free State, 2015-02)
English: The use of decellularized biological scaffolds for the reconstruction of small-diameter (< 6 mm) vascular grafts has been the focus of tissue engineering studies. These biological materials constructed through ...