Now showing items 11-20 of 27
DNA characterization of the FGA locus in the human genome
(University of the Free State, 2002-11)
English: The human alpha fibrinogen (FGA) short tandem repeat locus is found in the long arm of chromosome 4. It is located in the third intron of the alpha fibrinogen gene. This complex highly polymorphic tetranucleotide ...
The evaluation of tirofiban hydrochloride in a high shear rate arterial thrombosis model in baboons
(University of the Free State, 2009-11)
English: Background: Acute coronary syndrome (ACS) is a major cause of mortality and morbidity world-wide, and is responsible for roughly 2.5 million hospital admissions world-wide annually. ACS is commonly associated ...
A yeast-based assay for detection of mutations in the human p16 gene
(University of the Free State, 1999-05)
Cyclin-dependent kinases (CDKs) are crucial regulators of the cell cyele. CDKs themselves are subject to control by both cyelins and CDK inhibitors. Among the inhibitors, p 16 is very prominent, since it has been found ...
Co-expression and functional assay of human Rb and E2F1 proteins in yeast
(University of the Free State, 1999-09)
The mammalian cell cycle is composed of a myriad interactions occurring in a defined sequence dictated by the flow of entropy. The decision to study the cell cycle requires entry into a world where events take place, not ...
Construction of cDNA libraries, and the selection and expression of proteins and peptides involved in haemostasis
(University of the Free State, 2004-06)
English: The need to find new manners in which to combat cardiovascular disease and associated thrombotic complications, remains a high priority in industrialised countries. Even in third-world countries the implications ...
Microparticles derived from stimulation of human umbilical endothelium
(University of the Free State, 2013)
English: Endothelial microparticle reseach is currently a very novel and exciting topic in the field of haemosistasis and thrombosis. The role of microparticles in inflammatory and thrombotic disorders is however not ...
Genotypic and expression analysis of CYP3A4 and CYP3A5 in patients with chronic myeloid leukaemia
(University of the Free State, 2013-01)
Chronic myeloid leukaemia (CML) is a haematological malignancy characterised by the BCR-ABL fusion oncogene which encodes for a constitutively active tyrosine kinase. Imatinib mesylate is a tyrosine kinase inhibitor that ...
Prevalence of helicobacter pylori and its relation to cytotoxin-associated gene a status in HIV positive and negative haematology patients
(University of the Free State, 2007-10)
Abstract not available
The effect of inflammatory cytokines and coagulation factors on Von Willebrand factor synthesis and cleavage
(University of the Free State, 2012-02)
When injured, endothelial cells secrete inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-α (TNF-α). These inflammatory cytokines stimulate the endothelial release of ...
"Killer-cell immunoglobulin-like receptor haplotype diversity in three Free State population groups"
(University of the Free State, 2006-11)
English: In the foregoing project, an investigation was made into the relative KIR gene frequencies of three South African cohorts. Playing an important part in innate immunity, KIR fill a vital gap between viral onsets ...