Now showing items 1-10 of 26
The screening for single nucleotide polymorphisms of CYP3A4 in chronic myelogenous leukemia patients receiving imatinib
(University of the Free State, 2009-05)
English: Chronic myelogenous leukaemia (CML) is a malignant clonal disorder that results in the uncontrolled production of white blood cells. This disease is a result of a reciprocal translocation of the long arms of ...
Genotypic and expression analysis of CYP3A4 and CYP3A5 in patients with chronic myeloid leukaemia
(University of the Free State, 2013-01)
Chronic myeloid leukaemia (CML) is a haematological malignancy characterised by the BCR-ABL fusion oncogene which encodes for a constitutively active tyrosine kinase. Imatinib mesylate is a tyrosine kinase inhibitor that ...
The application of high-resolution melting curve analysis for the detection of mutations in the MCR-ABL kinase domain of patients with chronic myeloid leukaemia
(University of the Free State, 2011-12)
CML is a haematological malignancy that is characterized by the BCR-ABL fusion oncogene that encodes a constitutively active tyrosine kinase. The treatment of choice for CML is a tyrosine kinase inhibitor and molecular ...
Presence of glyphosate in food products in South Africa of which maize or soybean is the primary constituent
(University of the Free State, 2017-02)
English: South Africa is considered a major GM crop producing country. The predominant GM trait in maize and soybean in South Africa is herbicide tolerance. Herbicide tolerant (HT) crops allow for the application of herbicide ...
Molecular screening of Coloured South African breast cancer patients for the presence of BRCA mutations using high resolution melting analysis
(University of the Free State, 2016-08)
English: The populations of South Africa (SA) exhibit a rainbow of genetic diversity due to the high contribution of ancestral genetic admixture. The economic structure of this third world country has limited the exploration ...
Investigating the genetic profile of the E-cadherin gene in squamous carcinoma of the esophagus
(University of the Free State, 2003-06)
Molecular screening for the presence of large deletions or duplications in BRCA using Multiplex ligation-dependent probe amplification in South Africa
(University of the Free State, 2016-07)
English: Germline BRCA gene mutations are associated with hereditary breast and ovarian cancers (OVC). Identification of these mutations greatly improves the preventive strategies and management of patients affected with ...
Selection and characterization of a novel factor XI inhibiting peptide by using phage display technology
(University of the Free State, 2002-11)
English: The role of factor XI in hemostasis can be seen as a combination of a procoagulant action (the formation of fibrin) and an antifibrinolytic action (the protection of fibrin). High levels of factor XI lead to a ...
The evaluation of tirofiban hydrochloride in a high shear rate arterial thrombosis model in baboons
(University of the Free State, 2009-11)
English: Background: Acute coronary syndrome (ACS) is a major cause of mortality and morbidity world-wide, and is responsible for roughly 2.5 million hospital admissions world-wide annually. ACS is commonly associated ...
Characterization of a human inhibitory antibody fragment against tissue factor
(University of the Free State, 2011-11)
English: Tissue factor is a transmembrane glycoprotein that functions as the primary initiator of coagulation in response to mechanical or chemical damage. Due to its key position within the coagulation cascade it also ...